Setting Expectations for Adverse Effects
Considerations for a Confident Start on Orenitram
Starting Orenitram can be challenging, making it crucial to work together to proactively plan for expected adverse effects and help your patients stay on therapy.1,2
Adverse effects seen in FREEDOM-EV included headache, diarrhea, flushing, nausea, vomiting, as well as pain in the jaw, extremities, and upper abdomen.1
Before starting treatment1:
- Set expectations with patients on what to expect when starting treatment
- Have a plan in place with both your patient and your preferred Specialty Pharmacy to help manage expected adverse effects
- Take 3 times daily with food, ~8 hours apart
- Proactively use adjunctive pharmacotherapy
- Reduce dosage if needed
- Slow titration if needed
- Take with food
- Add fiber to diet
*Expert recommendations state that reassurance will suffice for flushing or jaw pain.2
†Separate prescription required.
‡Only recommended in severe cases.
Recommendations for adverse effect management were assembled by gathering information from a panel of Orenitram experts (N=11). This independent analysis used the Delphi process to cull panelists’ best practices for adverse effect management in patients taking Orenitram. Survey participants were from 11 centers and had a total experience of 206 patients.2
United Therapeutics does not provide medical advice. Adverse effect management strategies should be addressed in accordance with the Orenitram Full Prescribing Information and your clinical judgment.
Learn more about expert recommendations for managing expected adverse effects.Access Publication§ >
§Article may be restricted behind a paywall for nonsubscribers.
These considerations may help address challenges during treatment and help patients reach necessary exposure.2
Hear From PAH Experts
Franck Rahaghi, MD, and Starlet Harrimon, RN, discuss how they work with patients to plan for expected adverse effects with Orenitram.
Additional Support Resources
Side Effect Patient Guide
Preparing your patients for expected adverse effects may help them start Orenitram with confidence.
90-Day Trial Program
See how well your eligible patients may tolerate Orenitram at no cost for up to 90 days.
Specialty Pharmacy Support
Read about how Specialty Pharmacies may help your patients access Orenitram, schedule nurse visits, and much more.