Skip to content

You are using a browser that is not supported by this site. The site will not function properly. Please switch to the latest version of a supported browser such as Chrome, Safari, Edge, or Firefox to use this site.

United Therapeutics provides support for patients on Orenitram

The Orenitram 90-Day Trial Program allows you to assess how  well your patients tolerate Orenitram

Orenitram 90 day trial program
  • The program is offered to eligible patients at no cost for up to 90 days
  • Your patients have no obligation to continue taking Orenitram at the end of the trial period
  • Eligibility for this program is limited to patients with PAH (WHO Group 1) who have never been treated with Orenitram. Patients transitioning from another treprostinil medication are not eligible for this program


Your patients can start the 90-Day Trial Program through the Orenitram Titration Kit—providing a clear titration plan for the first 3 months of treatment.


The Archways program

Archways logo

Support for your patients as they begin their treatment with Orenitram

The United Therapeutics Archways program offers a variety of educational resources, including a Virtual Patient Educator, available at no cost for patients starting treatment with Orenitram, and their caregivers.

Once they’ve been prescribed Orenitram, patients can enroll in the Archways program. Patients will then be contacted by a United Therapeutics Virtual Patient Educator and will talk one-on-one via phone or video chat, to review:

  • Disease information
  • Details about starting Orenitram
  • Help with understanding their dosing schedule
  • What to expect when getting started in the Specialty Pharmacy process

3 ways to get started:


brochure icon

Call the Archways program at


connect icon

Text “START”“START” to 882724882724
(standard data rates may apply)

United Therapeutics and the Archways program do not provide medical advice. Patients are advised to consult with their HCP with any specific questions or concerns about their treatment.

Co-Pay Assistance Program

$0 Per Copay
Helps commercially insured patients save on each prescription of Orenitram. Eligible patients pay $0 per prescription.*

Eligibility Requirements For This Program

Patients must be 18 years or older to use this program.

Patients using Medicare, Medicaid, or any other state or federal government program to pay for their medications are not eligible. Patients who start utilizing government coverage during the term of the program will no longer be eligible.

The program is valid only for patients with commercial (also known as private) insurance who are taking the medication for an FDA-approved indication. The program is only valid for the cost of Orenitram and not applicable to any related supplies or other medical expenses associated with administering the product.

Eligible patients must be residents of the United States or Puerto Rico.

The program is subject to additional state law restrictions. Patients residing in select states may not be eligible for the program.

  • To enroll in this program, your patients must understand and agree to comply with the eligibility requirements and terms of use.
Terms & Conditions

Access and financial assistance

United Therapeutics Patient Assistance Program

Helping patients determine if they qualify for United Therapeutics’ Patient Assistance Programs

ASSIST, the Access Solutions and Support Team, is a United Therapeutics resource committed to helping eligible patients obtain access to their prescribed therapies. ASSIST can help PAH patients navigate topics such as insurance coverage, available financial assistance, and in-network pharmacies.

ASSIST offers support during the referral process

Through ASSIST, the Orenitram Referral Portal allows you to track the status of prescriptions for your patients who have been prescribed Orenitram.

Once you prescribe and submit the initial referral form, ASSIST will:

  • Obtain any additional information needed from your patients
  • Arrange for a Specialty Pharmacy to provide home medication delivery upon approval
  • Discuss financial assistance options that may be available for patients who qualify
Download the orenitram referral form view example referral form

To contact ASSIST, CALL 1-877-UNITHER (1-877-864-8437) or go to:

iAssist: Simple online referral system

United Therapeutics Patient Assistance Program

Orenitram is simplifying the referral process with iAssist

iAssist is a centralized hub for Orenitram that helps initiate and facilitate the referral process. iAssist is a streamlined solution that includes:

  • Advanced benefit verifications
  • Real-time electronic prior authorizations
  • Patient electronic consent
  • Electronic prescriptions and referral forms

With just a few clicks, your office can take advantage of this easy-to-use system for prescribing Orenitram.


Important Safety Information


  • Avoid use of Orenitram in patients with severe hepatic impairment (Child Pugh Class C) due to increases in systemic exposure.

Warnings and Precautions

  • Abrupt discontinuation or sudden large reductions in dosage of Orenitram may result in worsening of PAH symptoms.
  • The Orenitram tablet shell does not dissolve. In patients with diverticulosis, Orenitram tablets can lodge in a diverticulum.

Adverse Reactions

  • In the 12-week, placebo-controlled, monotherapy study, and an event-driven, placebo-controlled, combination therapy study, adverse reactions that occurred at rates at least 5% higher on Orenitram than on placebo included headache, diarrhea, nausea, vomiting, flushing, pain in jaw, pain in extremity, hypokalemia, abdominal discomfort, and upper abdominal pain.

Drug Interactions

  • Co-administration of Orenitram and the CYP2C8 enzyme inhibitor gemfibrozil increases exposure to treprostinil; therefore, Orenitram dosage reduction may be necessary in these patients.

Specific Populations

  • Animal reproductive studies with Orenitram have shown an adverse effect on the fetus. There are no adequate and well-controlled studies with Orenitram in pregnant women.
  • It is not known whether treprostinil is excreted in human milk or if it affects the breastfed infant or milk production.
  • Safety and effectiveness of Orenitram in pediatric patients have not been established.
  • Use of Orenitram in patients aged 65 years and over demonstrated slightly higher absolute and relative adverse event rates compared to younger patients. Caution should be used when selecting a dose for geriatric patients.
  • There is a marked increase in the systemic exposure to treprostinil in hepatically impaired patients.


Orenitram is a prostacyclin mimetic indicated for treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to delay disease progression and to improve exercise capacity. The studies that established effectiveness included predominately patients with WHO functional class II-III symptoms and etiologies of idiopathic or heritable PAH (66%) or PAH associated with connective tissue disease (26%).


Please see Full Prescribing Information and Patient Information for Orenitram.

For additional information, call 1-877-UNITHER (1-877-864-8437).

PAH=pulmonary arterial hypertension; WHO=World Health Organization.